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The key point of the initiative is the paradigm shift it proposes, as the study is carried out leaving behind the animal model and seeking a more ethical science, with experimental (in vitro) and computational (in silico) models.\n\nVISI-ON-BRAIN is designed to close the translational gap by building an integrated chain of predictive, reproducible, and clinically established experimental and computational tools, while training researchers who can operate at the interface of biology, data, engineering, and regulatory relevance.\n\nJosep M. 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